Engine Biosciences is a venture-backed company discovering and developing impactful precision medicines by deciphering complex biology with integrated computation and experimentation, with particular depth in oncology gained over several years of substantial investment and focus. Having pinpointed many promising drug targets and predictive biomarkers for patients most likely to benefit, Engine is advancing its pipeline of oncology therapeutics towards the clinic internally and with collaborators, and in other disease areas through partnerships. Engine’s team is motivated by opportunities to address significant unmet needs with more selective and effective precision medicines. For more information, please visit www.enginebio.com

We are a fast-paced, innovative company. We are excited to have passionate and talented staff join our team in Redwood City. We offer excellent career growth opportunities, and a chance to work closely with experienced entrepreneurs and leading scientists from industry and top international institutions.

We are looking for a highly motivated and experienced preclinical DMPK scientist to join our drug discovery team. You will lead the design and implementation of ADME and PK studies, analyzing and interpreting DMPK data, and providing input to project teams. You will enable the selection of development candidates for our product pipeline. You will manage collaborations with key advisors.

Responsibilities:

• Plan, execute, and report in vitro ADME studies managing diverse studies such as hepatocyte stability, plasma protein binding, permeability
• Lead PK aspects of the company’s ongoing preclinical and future clinical programs including liaison with CROs or project managers
• Provide strategic input on the design of DMPK experiments for DC selection and pre-IND studies
• Perform pharmacokinetic and pharmacodynamic modeling and simulation using software such as WinNonlin
• Interpretation of preclinical animal PK and TK data and prediction of human dose
• Identify CROs to conduct ADME and PK studies
• Collaborate with medicinal chemists, biologists to optimize the DMPK properties of drug candidates and address potential issues such as solubility, permeability, metabolism, and drug-drug interactions
• Work collaboratively with biology to interpret PK PD studies
• Communicate DMPK results and recommendations to project teams and senior management in a clear and concise manner
• Maintain a high level of scientific excellence and stay updated on the latest developments in the field of DMPK
• Manage the budget for the DMPK and PK/PD studies and related activities

Requirements:

• PhD or PharmD or equivalent in a relevant scientific discipline, with at least of 5 years directly related experience in preclinical DMPK
• Strong knowledge of pharmacokinetics and modeling, ADME concepts, PKPD principles, and clinical pharmacology
• Experience in drug discovery and in vivo evaluation of drugs
• Expertise in conducting and interpreting in vitro and in vivo ADME studies
• Familiarity with Phoenix WinNonlin, NONMEM, or other pharmacokinetic and modeling software
• Prior direct CRO management experience
• Prior experience authoring relevant sections of regulatory applications including IND, IMPD, NDA is a plus
• Excellent oral and written communication skills for effectively interfacing with all levels of management and departments within the company
• Experience in working with small molecules in oncology
• Strong problem-solving and analytical skills
• Ability to work independently and collaboratively in a fast-paced environment